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Various factors including the seasons, climate, and stress can affect its development.

The endometrium itself produces certain hormones at different stages of the cycle and this affects other parts of the reproductive system.

In both cases, the endometrium initially proliferates under the influence of estrogen.

However, once ovulation occurs, in addition to estrogen, the ovary will also start to produce progesterone.

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The endometrium develops at different rates in different mammals.

The endometrium is central, echogenic (detectable using ultrasound scanners), and has an average thickness of 6.7 mm.

The endometrial lining undergoes cyclic regeneration. Humans and great apes display the menstrual cycle, whereas most other mammals are subject to an estrous cycle.

The endometrium is the inner epithelial layer, along with its mucous membrane, of the mammalian uterus.

It has a basal layer and a functional layer; the functional layer thickens and then is sloughed during the menstrual cycle or estrous cycle.